The Dr. Anastácio Gonçalves House-Museum is a museum space in the city of Lisbon showcasing the collection gathered by the physician and collector António Anastácio Gonçalves.

The group of about 3,000 works of art comprises three major groups: Portuguese painting from the 19th and 20th centuries, Chinese porcelain, and Portuguese and foreign furniture. This museum features also an important section with civil and sacred jewellery, European painting, Portuguese sculpture, European ceramics, textiles, numismatics, medals, glassware and pocket watches of Swiss and French manufacture. In addition to the works gathered by the collector, this House-Museum contains a significant documentary collection and a number of drawings, watercolours and small artefacts belonging to the estate of the painter Silva Porto.

The current Dr. Anastácio Gonçalves House-Museum, a project by the architect Norte Júnior dated 1904-05, was built by the painter José Malhoa to serve as both his home and work studio. This was the artist's first house in the capital, awarded with a Prémio Valmor in 1905 and was integrated urbanistically into the development plan of the city of Lisbon. The “Casa-Malhoa” was acquired in 1932 by Dr. Anastácio Gonçalves (1889-1965), who lived there and organized his collection. In 1969, at the collector's express will, the building was bequeathed to the Portuguese State in order to create a Museum that would be opened to the public in 1980.

In 1996, under a project of the architects Frederico and Pedro George, works of expansion and improvement were carried out and the adjoining house, also signed by Norte Júnior, was attached to the original building The new space provided the extension of the visitor's reception area with a shop and space to accommodate temporary exhibitions. The Dr. Anastácio Gonçalves House-Museum reopened in December 1997 with its current configuration.